Genetics influences body fat accumulation

Obesity remains a worldwide pandemic.
In our modern era, no clear answer exists to a seemingly simple question:

•  Why have so many people become too fat? 
• What can be done to reduce the problem? 

If you asks the above questions to the healthcare professionals or allied health professionals, No doubt, You will get a tons of answers based on the scientific background and self-experience as well.

 Among most of the complex interactions in over fatness. Here, I'm intending to write this article to express my view on how genetics influences body fat accumulation. 

 Research with specific segments of the population attributes up to 80% of the risk of becoming obese to genetic factors. 

 For example, 

 Overweight parents: Newborns with large body weight becomes fat adolescents only when the father or particularly the mother is overweight. 

Normal weight parents: Little risks exists for an overweight toddler to grow into an obese adults, If both parents are of normal weight. 

     Leptin: A hormone, which trigger signal which largely determines, How much one eats, How much one expends, and ultimately how much one weighs.

 Mechanism: 

 1. The ob gene inside of the fat cell creates leptin. 

 2. Leptin moves fat cells and enters into blood stream. 

 3. Leptin signals the hypothalamus to reduce or stop the drive to eat after the 'setpoint' is reached for the body's total fat content.

 Leptin may affect certain neurons in the hypothalamic region that stimulate the production of chemicals that suppress appetite and/or reduce the levels of neurochemicals that stimulate appetite.

 'If' conditions: 

 1. 'IF' The energy balance remains in steady state then, the plasma leptin is normal and direct proportion to the adipose(fat) tissue mass, 

 2. 'IF' High blood leptin is present, then it is associated strongly with obesity.

 3. 'IF' Low blood leptin is present, then weight loss occurs. 

 In the bottom line,

•  Ones genetics makes up does not necessarily cause obesity, but instead lowers the threshold for its development.
•  The linkage of genetic and molecular abnormalities to obesity allows us to view overfatness as a disease than a psychologic flaw.