"Rapid and large accumulation of blood lactate occur during maximal exercise that lasts between 60 and 180 seconds. Decrease the intensity of exercise that decreases the rate of lactate accumulation and final blood lactate".
Lactate Accumulation:
- Blood lactate doesn't accumulate at all levels of exercise. In biochemical terms, energy generated from the oxidation of hydrogen provides the predominant ATP fuel for muscular activity.
- Any lactate formed in one part of the working muscles becomes rapidly oxidized by muscle fibers with high oxidative capacity in the same muscle
- When lactate oxidation equals its production, blood lactate level remains stable even though increases in occur in exercise intensity and oxygen consumption.
- Tendency for the enzyme Lactate dehydrogenase (LDH) in fast twitch muscle fibers to favor the conversion of pyruvate to lactate, whereas LDH in slow twitch muscle fibers to favor the conversion of lactate into pyruvate.
"When glycolytic metabolism predominates, Nicotamine adenine dinucleotide (NADH) production exceeds the cell's capacity for shuttling its hydorgen(electrons) down the respiratory chain because of the insufficient oxygen supply (or use) at the tissue levels. Imbalances in hydrogen release and subsequent oxidation causes pyruvate to accept excess hydrogen. The pyruvate with 2 hydrogen forms lactic acid, Which begins to accumulate.Blood lactate accumulates only when its disapperance does not match its production.
Favorable aerobic response relates to lactate formation:
- An individual specific genetic endowment(Muscle fiber type, muscle blood flow responsiveness)
- Specific local training and adaptations that favor less lactate production.
- More rapid rate of lactate removal at any exercise intensity.
- Low tissue oxygen'
- Reliance on glycolysis
- Activation of fast-twitch muscle fibers
- Reduced Lactate removal
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